Select SAUTE setting on Instant Pot. Add beef, onion, and garlic and cook for 8 minutes, until beef is browned. Use a meat chopper or wooden spoon to break up meat as it is browning. Once complete, press CANCEL.
Add sauce, water, and wine, stir until combined, then add spaghetti and stir.
Using MANUAL setting, set for 8 minutes, then quick release.
Stir In milk and pepper, cover, and allow to rest for 5 minutes to thicken. Serve and sprinkle with parmesan cheese.
Notes
*If not using extra lean ground beef, drain some of the fat (or soak up with a paper towel) before step 2.
Refrigerate leftovers up to 4 days, or freeze in zip bags for up to 3 months. To save space, fill the bags and lay flat until frozen.